Definition:
Osteogenesis imperfecta (OI) is a genetic disorder in which the body either does not make enough collagen or makes defective collagen. Since collagen provides structure for the bones, children with OI have bones that are less dense than normal and easily broken. OI can be passed on by a parent or can be the result of a spontaneous genetic mutation. Of the four types of OI, Type II is the most serious, often causing death soon after birth; Type I is the mildest and may improve after puberty; and Type III and IV fall somewhere in between.
Also Known As: Brittle Bone Disease, Brittle Bone Disorder
